Final answer:
The kidneys play a crucial role in the regulation of blood volume by managing the amount of water, ions, and substances in the blood, thus affecting blood pressure and overall homeostasis.
Step-by-step explanation:
The statement that the kidneys play a major role in regulating blood volume is true. The kidneys are crucial in maintaining homeostasis by regulating the amount of water, ions, and other substances in the blood. They control blood volume and blood pressure by determining fluid loss in the form of urine and by releasing hormones such as renin, which is part of the renin-angiotensin-aldosterone system.
Kidneys contribute to other homeostatic functions as well by secreting hormones like erythropoietin (EPO) that stimulate red blood cell production and calcitriol, the active form of vitamin D for bone health. Moreover, the kidneys help regulate solute concentration in the blood to ensure proper cellular function and they also manage blood pH together with the lungs and plasma buffers.