Final answer:
The Grants' long-term study of the medium ground finch on Daphne Major provides evidence for the strength and direction of selection varying over time.
Step-by-step explanation:
The Grants' long-term study of the medium ground finch on Daphne Major provides evidence for both factors A and B. During a drought period in 1977, the vegetation on the island was altered, causing a decline in small, soft seeds. The large-billed birds were able to survive better than the small-billed birds, indicating that the strength and direction of selection varies over time.
Based on the study, it can be concluded that the Grants' long-term study demonstrates that the strength of selection and the direction of selection can vary over time, supporting option D.