Question

In Parkinson's disease patients, alpha-SYN is upregulated forming Lewy bodies which essentially cause apoptosis in neurons. Smoking allows for rapid introduction of Nicotine into neurons. Nicotine is known to upregulate miRNA 214 in neurons. The western blot below exhibits a SYN in the presence of varying concentrations of miRNA-214. Which of the following supports the data?

A. Increase in miRNA-214 correlates with decreased SYN levels
B. Nicotine has no effect on SYN expression
C. Decrease in miRNA-214 correlates with increased SYN levels
D. Nicotine-induced upregulation of miRNA-214 enhances SYN expression

Answer 1

The western blot data supports option D: Nicotine-induced upregulation of miRNA-214 enhances SYN expression.

Step-by-step explanation:

The western blot data supports option D: Nicotine-induced upregulation of miRNA-214 enhances SYN expression. In Parkinson's disease, alpha-SYN is upregulated forming Lewy bodies, leading to apoptosis in neurons. Nicotine, when introduced into neurons, upregulates miRNA-214.

The western blot exhibits SYN levels in the presence of varying concentrations of miRNA-214. The data shows that as miRNA-214 increases, SYN levels also increase, indicating that nicotine-induced upregulation of miRNA-214 enhances SYN expression.