Question

Cell signaling is also in bacteria! Hydrogen peroxide induces rsp expression in Staphylococcus aureus. Rsp is a transcription factor. Neutrophils are PMN's that phagocytize and kill bacteria with H2O2. Nuc is a virulrent protein. Based off the data below place the signal mechanism (chain of events) in order.

I: RSP unregulated expression of virulence genes
II: H2O2 induces expression of rsp in WT. s aureus
III: neutrophil phagocytizies S. aureus as a host defense
IV: Nuc and other proteins lyse neutrophils
a) II, III, I , IV
b) III, I, II, IV
c) III, IV, II, I
d) III, II, I, IV

Answer 1

The correct sequence of events for Staphylococcus aureus responding to neutrophil action with H2O2 is: neutrophil phagocytosis (III), rsp induction by H2O2 (II), rsp upregulates virulence genes (I), and the release of Nuc to lyse neutrophils (IV).

Step-by-step explanation:

The ordering of signal mechanism (chain of events) for Staphylococcus aureus response to neutrophil action and hydrogen peroxide (H2O2) is critical in understanding the interactions between a host's immune response and bacterial defense mechanisms.

1. Neutrophil phagocytizes S. aureus as a host defense (III).
2. H2O2 induces expression of rsp in WT. S. aureus (II).
3. RSP upregulated expression of virulence genes (I).
4. Nuc and other proteins lyse neutrophils (IV).

This sequence starts with the immune system's response to S. aureus and follows through the bacterial response that includes the activation of a transcription factor and the eventual lyse of neutrophils, illustrating a complex interaction between host and pathogen.