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Why is a mechanism for segregation not important for high-copy plasmids?

User Aaronfay
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Final answer:

A segregation mechanism is less crucial for high-copy plasmids because their abundance in bacterial cells generally ensures distribution to daughter cells after cell division, unlike the precise requirements needed for chromosomal DNA segregation.

Step-by-step explanation:

A mechanism for segregation is not important for high-copy plasmids because they are present in large numbers within the bacterial cell, which reduces the impact of not segregating perfectly during cell division. In contrast to chromosomal DNA, which is present in just one or two copies and requires precise segregation mechanisms to ensure each daughter cell inherits a complete set of genetic information, high-copy plasmids rely on their sheer abundance to ensure that both daughter cells receive at least some plasmids after cell division.

Furthermore, any bacteria that do not receive plasmids post-division are likely to be outcompeted by those that do, due to the advantageous genes that plasmids can carry, such as those providing antibiotic resistance. Therefore, while mechanisms like cut-and-paste transposition or replicative transposition play roles in ensuring the distribution of transposons within the genome, these precise mechanisms are not as critical for the segregation of high-copy plasmids.

User Fabian Linzberger
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