Final answer:
Adenovirus uses an RNA intermediate to replicate both strands of its double-stranded DNA genome. The RNA serves as a template for the synthesis of mRNA and the complementary DNA strand, which then acts as a template for the synthesis of the second DNA strand.
Step-by-step explanation:
The viral genome of Adenovirus is double-stranded DNA, however, it uses an RNA intermediate for replication. The viral RNA serves as a template for the synthesis of both mRNA and the complementary DNA strand. The RNA is first transcribed into mRNA, which can be directly translated to produce viral proteins, or it can serve as a template for the synthesis of the complementary DNA strand by an enzyme called reverse transcriptase. This complementary DNA strand can then be used as a template for the synthesis of the second DNA strand, completing the replication process.