Final answer:
Acute leukemias often involve chromosomal translocations, which are rearrangements of chromosome sections that can lead to certain forms of leukemia, including chronic myelogenous leukemia with the Philadelphia chromosome.
Step-by-step explanation:
A large fraction of the acute leukemias are associated with chromosomal translocations. This involves sections of chromosomes being relocated, either to another chromosome or a different part of the same chromosome. These translocations are significant in the development of certain forms of leukemia, such as chronic myelogenous leukemia, where a well-known example is the translocation of chromosomes 9 and 22, creating the Philadelphia chromosome. This results in the production of the BCR-abl fusion protein, an oncogenic tyrosine kinase. Although other factors like epigenetic inheritance can also play a role in leukemia, translocations are a primary concern in acute leukemias.