Final answer:
A loss-of-function mutation occurs when the wildtype allele of a recessive tumor suppressor gene is eliminated or mutated, leading to non-functionality. This type of mutation is often associated with the development of cancer.
Step-by-step explanation:
The result of any of several genetic aberrations in which the wildtype allele of a recessive tumor suppressor gene is eliminated or mutated is known as a loss-of-function mutation. Loss-of-function mutations occur when one copy of the tumor suppressor gene is mutated or eliminated, rendering it non-functional. These mutations are often associated with the development of cancer.