Final answer:
Synaptic plasticity is largely dependent on the increase of Ca2+ ion in the postsynaptic cell. When an action potential reaches the axon terminal, voltage-gated Ca2+ channels open and allow Ca2+ to enter the cell.
Step-by-step explanation:
Synaptic plasticity is largely dependent on the increase of Ca2+ ion in the postsynaptic cell. When an action potential reaches the axon terminal, voltage-gated Ca2+ channels open and allow Ca2+ to enter the cell. The increase in Ca2+ concentration inside the end bulb facilitates the release of neurotransmitters into the synaptic cleft, which plays a crucial role in synaptic plasticity.