Final answer:
The least accurate statement is that voltage gated sodium channels would precede voltage gated calcium channels at the neuromuscular junction, as calcium channels open first to release neurotransmitter.
Step-by-step explanation:
The statement that is the least accurate is: b) activation of voltage gated sodium channels would precede voltage calcium channels at the neuromuscular junction. At the neuromuscular junction, the action potential arriving at the nerve terminal leads to the opening of voltage-gated calcium channels first, which is a crucial step for the release of neurotransmitters into the synaptic cleft. Only after neurotransmitter release and binding to receptors on the muscle cell, will the sodium channels open as a response to the ligand binding, which may then facilitate an action potential in the muscle cell.
An ionotropic receptor is indeed both an ion channel and is ligand-gated, meaning it opens in response to the binding of a neurotransmitter. G-protein coupled receptors (metabotropic receptors) do not form an ion channel but can activate secondary messenger pathways, thus increasing the complexity of the response in the postsynaptic cell.