Final answer:
The most accurate statement is that calcium increases in the presynaptic cell prior to vesicle fusion with the membrane in a chemical synapse.
Step-by-step explanation:
The most accurate statement is C. Calcium increases in the presynaptic cell prior to vesicle fusion with the membrane.
During communication at a chemical synapse, when the presynaptic membrane is depolarized, voltage-gated Ca²+ channels open and allow Ca²+ to enter the cell.
The influx of calcium ions initiates a signaling cascade that leads to the fusion of synaptic vesicles with the presynaptic membrane and the release of neurotransmitter molecules into the synaptic cleft. Therefore, calcium increases in the presynaptic cell before vesicle fusion.