Final answer:
The mottled color suggests that in a population of cells both X-chromosomes are active.
Step-by-step explanation:
The correct statement is D. The mottled color suggests that in a population of cells both X-chromosomes are active. The mottled coloring in calico cats is due to X-chromosome inactivation during embryonic development. In female cats, one of the two X chromosomes is randomly inactivated in each cell, resulting in a tortoiseshell pattern if the cat has two different alleles for coat color. This means that each cell in the cat's body can have different X-chromosomes inactivated, resulting in mottled colors.