Question

Fructose 1, 6-bisphosphatase is a key regulatory enzyme in gluconeogenesis. This enzyme is allosterically regulated by a number of different metabolites, both negatively and positively. Which molecule below would be an allosteric activator of this enzyme?

A. NADH
B. ADP
C. AMP
D. NAD+

Answer 1

ADP is an allosteric activator of fructose-1,6-bisphosphatase, a key regulatory enzyme in gluconeogenesis.

Step-by-step explanation:

Fructose-1,6-bisphosphatase is a key regulatory enzyme in gluconeogenesis. It is allosterically regulated by various metabolites. An allosteric activator of this enzyme is ADP. When ADP levels are high, the enzyme is more active.

ADP acts as a positive regulator and stimulates the breakdown of fructose-1,6-bisphosphate, promoting gluconeogenesis.