Question

A neurotransmitter triggers the opening of chloride ion (Cl-) channels on the post-synaptic cell membrane. Chloride ions enter the cell, down their concentration gradient, What effect will this have on the post-synaptic neuron?

Answer 1

The entry of chloride ions through open channels in the post-synaptic neuron hyperpolarizes the membrane, leading to an inhibitory postsynaptic potential (IPSP).

Step-by-step explanation:

The effect of chloride ions entering the post-synaptic neuron through open chloride ion (Cl-) channels depends on the neurotransmitter. In the case of GABA (gamma-aminobutyric acid), the primary inhibitory neurotransmitter, the entry of Cl- ions hyperpolarizes the membrane of the post-synaptic neuron, making it less likely to fire an action potential. This is known as an inhibitory postsynaptic potential (IPSP).