Question

MHC molecules do not play a role in transfusion reaction because erythrocytes do not express the MHC molecule.

a-true
b-false

Answer 1

MHC molecules do play a role in transfusion reactions, but not in the same way as in organ transplantation.

Step-by-step explanation:

MHC molecules do play a role in transfusion reactions, but not in the same way as they do in organ transplantation.

In transfusion reactions, erythrocytes (red blood cells) do not express MHC molecules. Instead, transfusion reactions occur when the recipient's antibodies recognize antigens on the donor's red blood cells as foreign and launch an immune response. This can lead to the destruction of the transfused red blood cells.

In contrast, in organ transplantation, MHC molecules on the donor organ play a major role in determining compatibility. If the MHC molecules on the donor organ are different from those of the recipient, the recipient's immune system may recognize the organ as foreign and mount an immune response that can lead to rejection of the transplanted organ.