Final answer:
When the parathyroid gland fails to respond to calcium bound to its receptors, it can lead to a condition known as hypoparathyroidism, which can result in decreased blood calcium levels and various symptoms. The inability to maintain normal blood calcium levels can also affect bone health.
Step-by-step explanation:
When the parathyroid gland fails to respond to calcium bound to its receptors, it can lead to a condition known as hypoparathyroidism. In this condition, the parathyroid gland is unable to produce enough parathyroid hormone (PTH) or the hormone is not functioning properly. This can result in decreased blood calcium levels, which can lead to symptoms such as muscle cramps, tingling or numbness in the hands and feet, and seizures.
Additionally, without PTH stimulation, the kidneys may not reabsorb enough calcium from the urine, leading to increased calcium excretion. The inability to maintain normal blood calcium levels can also affect bone health, as PTH normally stimulates osteoclast activity and inhibits osteoblast activity, which helps maintain bone density.
Overall, the effects of the parathyroid gland failing to respond to calcium bound to its receptors can disrupt the body's calcium homeostasis and lead to various symptoms and complications.