Final answer:
Anisocytosis can be determined using RDW as a mathematical index (Option 2).
Step-by-step explanation:
Anisocytosis can be determined using RDW (Red Cell Distribution Width) as a mathematical index. Anisocytosis refers to having a population of red blood cells (RBCs) that are of unequal sizes. This condition is commonly seen in various types of anemia, and it is one aspect that medical professionals evaluate when diagnosing blood disorders.
MCV (Mean Corpuscular Volume) measures the size of red blood cells and is used to categorize anemias as microcytic, normocytic, or macrocytic based on whether the cells are smaller, normal, or larger than average respectively. However, the RDW specifically measures the range of variation in size of RBCs, and a high RDW indicates a greater variance in RBC size, which is indicative of anisocytosis.
Thus, the correct option is number 2.