Question

While ________ is released early in the inflammatory response to inhibit blood clotting, the ________ that have leaked into the interstitial space become active and isolate the region of damage.

A) bradykinin : defensive proteins B) histamine : defensive proteins
C) histamine : clotting factors
D) bradykinin : albumin molecules
E) heparin : clotting factors

Answer 1

Histamine is released early in the inflammatory response to dilate blood vessels and increase their permeability. The clotting factors that have leaked into the interstitial space become active and form a blood clot.

Step-by-step explanation:

The correct answer is C) histamine: clotting factors.

During the inflammatory response, histamine is released early to dilate blood vessels (vasodilation) and increase their permeability, allowing plasma and inflammatory mediators to leak into the interstitial space. This causes the swelling associated with inflammation. Meanwhile, the clotting factors, which are found in the plasma, become active and form a blood clot, isolating the region of damage.

For example, the release of histamine by injured cells and mast cells causes vasodilation, leading to increased blood flow and the leakage of clotting factors into the interstitial space. These clotting factors then activate and initiate the clotting cascade, ultimately forming a blood clot to seal off the damaged area.