Final answer:
Helper T cell proliferation is triggered by the release of interleukin-2, which is produced by the T cell itself after activation by an antigen-presenting cell with an MHC II receptor.
Step-by-step explanation:
Activation of helper T cell proliferation, once it has bound to its major histocompatibility (MHC) molecule, involves the release of interleukin-2 (IL-2) from the T cell itself after becoming activated by an antigen-presenting cell (APC) presenting an antigen via the MHC II receptor. These cytokines are essential for the activation and proliferation of T cells, leading to an immune response.