Question

Selective serotonin reuptake inhibitors allow for _______________________ in the post synaptic cell in a synapse because they ______________________.

a. more inhibition; slow neurotransmitter release
b. more excitation; block the serotonin reuptake protein
c. more excitation; inhibit the modulatory inhibitory interneuron
d. more inhibition; excite the modulatory inhibitory interneuron
e. more excitation; increase the affinity of the post synaptic receptor

Answer 1

SSRIs cause more excitation in the postsynaptic cell by blocking the reuptake of serotonin, leading to increased serotonin in the synaptic cleft and enhanced interaction with postsynaptic receptors.

Step-by-step explanation:

Selective serotonin reuptake inhibitors (SSRIs) allow for more excitation in the postsynaptic cell in a synapse because they block the serotonin reuptake protein. This blockage results in an increase in serotonin in the synaptic cleft by preventing its reabsorption into the presynaptic neuron. The accumulation of serotonin in the synaptic cleft enhances its effect, giving it more time to interact with receptors on the postsynaptic cell, and typically, this leads to increased neural activity or excitation. Common SSRIs such as Prozac, Paxil, and Zoloft are used to treat conditions like depression by exploiting this mechanism. These medications effectively increase serotonin levels in the central nervous system and contribute to elevated mood and reduced depressive symptoms.