Question

From IgG to IgG where do you expect to find the greatest amino acid differences? Constant regions or variable regions and if the answer is the variable regions, which specific regions of the variable regions?

Answer 1

The greatest amino acid differences in IgG molecules are found in the hypervariable regions of the variable regions, specifically at positions 31-37, 51-68, 86-91, and 101-109 of the V₁ region of heavy chains.

Step-by-step explanation:

When comparing amino acid differences in IgG molecules, you will find the greatest variation in the variable regions relative to the constant regions. Specifically, within the variable regions, the hypervariable regions or complementarity determining regions (CDRs) show marked variability in amino acid sequence composition. These regions are responsible for binding to specific antigens and are found at positions 31-37, 51-68, 86-91, and 101-109 in the V₁ region of heavy chains. They are held in place by more conserved framework regions that constitute 80-85% of the structure.