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What is virus-mediated bacterial recombination?

User Yena
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Virus-mediated bacterial recombination involves the horizontal gene transfer facilitated by bacteriophages, resulting in genetic variations that can have significant impacts on bacterial populations, such as the spread of antibiotic resistance and the emergence of new pathogenic strains.

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Virus-Mediated Bacterial Recombination

Virus-mediated bacterial recombination is a process of horizontal gene transfer, where viruses, specifically bacteriophages, transfer genetic material from one bacterium to another. This genetic exchange can occur when a bacteriophage infects a bacterial cell and incorporates its DNA into the host cell genome. This form of recombination can lead to significant genetic variation in bacterial populations and contributes to phenomena such as the spread of antibiotic resistance and increased pathogenicity.

Transduction is the mechanism of horizontal gene transfer in bacteria in which bacteriophages carry genes from one bacterium to another during infection. Genetic recombination through this method is particularly impactful, as it can combine gene segments from different bacterial strains or species, leading to novel genetic combinations. An example of this was the recombination between human and pig influenza viruses that contributed to the 2010 H1N1 swine flu outbreak.

Bacterial cells can also undergo genetic recombination through other processes such as conjugation, where DNA is exchanged through physical contact, or transformation, in which cells take up environmental DNA from their surroundings. Yet, it is the virus-mediated approach that is often harnessed in biotechnological applications like the engineering of recombinant DNA into phagemids, which can be introduced into bacterial cells in the laboratory setting.

User Bart Hofland
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