Question

Which of the following is FALSE regarding similarities between estrogen and testosterone? (assume a non-pregnant female)

1) Both estrogen and testosterone promote secondary sex characteristics
2) Both estrogen and testosterone are secreted by something in the gonads
3) Both estrogen and testosterone exert negative feedback on LH, FSH and GnRH
4) None of the above, (i.e. ALL ARE TRUE)
5) Both estrogen and testosterone exert local positive feedback on cells in the gonads

Answer 1

The false statement is that both estrogen and testosterone exert local positive feedback on cells in the gonads, as this generally only occurs with estrogen during the midpoint of the menstrual cycle.

Step-by-step explanation:

The false statement regarding similarities between estrogen and testosterone is that both hormones exert local positive feedback on cells in the gonads, or statement 5 in the initial list. In actuality, high levels of estrogen can create a positive feedback loop but only during the midpoint of the menstrual cycle, leading to an LH surge that triggers ovulation. Conversely, these hormones typically exert negative feedback on the secretion of LH, FSH, and GnRH to maintain hormonal balance. Both testosterone and estrogen do stimulate the development of secondary sex characteristics, and both are indeed secreted by the gonads.