Question

Which of the following correctly depicts the control of secretion of glucocorticoids?

1) central nucleus of the amygdala → activates ACTH secretion from anterior pituitary - > PVN activation → glucocorticoid secretion from adrenal medulla
2) CRH secretion within the PVN → activates ACTH release from anterior pituitary → glucocorticoid secretion from adrenal cortex
3) PVN activation → CRH secretion in anterior pituitary → ACTH secretion from anterior pituitary - > glucocorticoid secretion from adrenal cortex
4) ACTH secretion from the PVN → CRH release from the posterior pituitary → glucocorticoid secretion from adrenal cortex
5) activation of the central nucleus of the amygdala → sympathetic activation → adrenaline release → glucocorticoid secretion from adrenal cortex

Answer 1

The control of secretion of glucocorticoids is correctly depicted by option 2) CRH secretion within the PVN → activates ACTH release from anterior pituitary → glucocorticoid secretion from adrenal cortex.

Step-by-step explanation:

The control of secretion of glucocorticoids is correctly depicted by option 2) CRH secretion within the PVN → activates ACTH release from anterior pituitary → glucocorticoid secretion from adrenal cortex.

In this pathway, corticotropin-releasing hormone (CRH) is secreted from the hypothalamic paraventricular nucleus (PVN). CRH then stimulates the release of adrenocorticotropic hormone (ACTH) from the anterior pituitary. Finally, ACTH stimulates glucocorticoid secretion from the adrenal cortex.

CRH, ACTH, and glucocorticoids are part of the hypothalamic-pituitary-adrenal (HPA) axis, which regulates the stress response and other physiological processes.