Final answer:
Prolonged stress leads to cardiovascular disease largely due to an increase in blood pressure and sustained activation of the sympathetic nervous system, adding wear and tear to the cardiovascular system and contributing to the development of diseases like hypertension and heart failure.
Step-by-step explanation:
Prolonged stress can result in cardiovascular disease primarily because of options 2) stress can increase blood pressure which leads to heart attacks and strokes, and 5) activation of the sympathetic nervous system produces more wear and tear on the cardiovascular system.
The physiological basis of stress involves a complex network of physiological responses that are highly beneficial in acute, short-term situations but potentially damaging when these responses are persistently activated over the long term. The stress hormone cortisol, for instance, can weaken immune system functioning, and the cardio strain from high blood pressure can set the stage for heart attack or heart failure.