Final answer:
The most therapeutic response for the nurse to give in this situation would be option 1) 'You seem upset. Let's talk about what's bothering you.' correct option is 1.
Step-by-step explanation:
The most therapeutic response for the nurse to give in this situation would be option 1) 'You seem upset. Let's talk about what's bothering you.' This response shows empathy and a willingness to listen to the client's feelings of loneliness and offer support through conversation. It acknowledges the client's emotions and opens up an opportunity for the nurse to provide comfort and understanding.