Final answer:
A diploid species with three sets of homologous chromosomes can produce up to 8 different combinations of chromosomes in its gametes according to the 2n rule.
Step-by-step explanation:
Based on the 2n rule, a diploid species that has three sets of homologous chromosomes can have up to 8 different combinations of chromosomes in its gametes. This is because the number of possible combinations of chromosomes is given by 2n, where n is the number of homologous chromosome sets. In this scenario, with n = 3, we calculate the number of combinations by raising 2 to the 3rd power - which equals to 2 x 2 x 2, thus resulting in 8 different combinations.