Final answer:
The success of the RYGB procedure in treating obesity is largely attributed to the disruption of ghrelin secretion, which helps reduce hunger and food intake.
Step-by-step explanation:
Among the options provided, the key factor for the success of the Roux-En-Y Gastric Bypass (RYGB) procedure for the treatment of obesity is that it disrupts the secretion of ghrelin. The RYGB procedure involves creating a small pouch from the stomach and connecting it directly to the small intestine, bypassing a large portion of the stomach and the duodenum. This modification not only limits the intake of food due to the smaller size of the stomach pouch but also leads to a significant reduction in the secretion of ghrelin, a hormone that stimulates hunger. Since the cells that produce ghrelin are primarily located in the part of the stomach that is bypassed, the levels of ghrelin decrease after the surgery, reducing hunger and aiding in weight loss.