Question

Which of the following is true of Parkinson's disease (PD)?

1) PD is a rare neurodegenerative syndrome.
2) Nigrostriatal neurons die in PD.
3) Most cases of PD are inherited.
4) Muscle flacidity is a PD symptom.
5) Early intervention can cure PD.

Answer 1

The true statement about Parkinson's disease (PD) among the options provided is 2) Nigrostriatal neurons die in PD.

Step-by-step explanation:

Parkinson's disease (PD) is a neurodegenerative disorder that affects predominantly dopamine-producing neurons in a specific area of the brain known as the substantia nigra. Symptoms generally develop slowly over years, and can include tremors, limb rigidity, and problems with the balance and gait.

Among the statements provided, the following is true:

1. PD is a rare neurodegenerative syndrome. - This is not true; PD is relatively common, especially in older individuals.
2. Nigrostriatal neurons die in PD. - This is true; the disease is characterized by the loss of dopaminergic neurons in the substantia nigra.
3. Most cases of PD are inherited. - This is not true; most cases of PD are sporadic and not directly inherited, although genetics can play a role.
4. Muscle flacidity is a PD symptom. - This is not true; muscle rigidity is a symptom of PD, not flaccidity.
5. Early intervention can cure PD. - This is not true; there is no cure for PD, but early intervention can help manage symptoms and improve quality of life.

Treatments for PD are primarily focused on treating symptoms and may include medications and surgical therapy, but as the disease progresses, these become less effective and may have significant side effects.

Hence, the correct answer is Option 2.