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Which of the following is true regarding CART?

1) Infusion of an antibody to CART decreases feeding.
2) CART is a peptide localized within the area postrema.
3) CART inhibits eating.
4) CART is excitatory for MCH/orexin neurons.
5) CART is the precursor molecule for the synthesis of CCK.

User Denmch
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1 Answer

4 votes

Final answer:

CART (Cocaine- and Amphetamine-Regulated Transcript) is a neuropeptide that inhibits eating and regulates feeding behavior. The correct option given is that CART inhibits eating, which is consistent with its appetite-suppressing effects observed in central administration.

Step-by-step explanation:

The student's question is about the functions and characteristics of Cocaine- and Amphetamine-Regulated Transcript (CART), a neuropeptide that plays a role in the regulation of feeding behavior. Out of the provided options regarding CART:

  1. Infusion of an antibody to CART decreases feeding.
  2. CART is a peptide localized within the area postrema.
  3. CART inhibits eating.
  4. CART is excitatory for MCH/orexin neurons.
  5. CART is the precursor molecule for the synthesis of CCK.

The correct statement is the third one: CART inhibits eating. CART has been shown to suppress appetite and feeding when administered centrally, suggesting its role in weight regulation and obesity. Other options provided about the localization and effects of CART, as well as its role as a precursor, are not well established or are incorrect.

User Kartos
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