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What are the properties of Class 1 MHC molecules?

1) They are found on the surface of all nucleated cells
2) They present antigens to CD8+ T cells
3) They are involved in the recognition of self and non-self antigens
4) They are encoded by the HLA-A, HLA-B, and HLA-C genes

User Wes Nolte
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Final answer:

Class 1 MHC molecules are present on all nucleated cells, present antigens to CD8+ T cells, are involved in self and non-self antigen recognition, and are encoded by the HLA-A, HLA-B, and HLA-C genes.

Step-by-step explanation:

Properties of Class 1 MHC Molecules

Class 1 MHC (major histocompatibility complex) molecules have several distinct properties that are vital to their role in the immune system:

They are expressed on the surface of all nucleated cells, which allows them to present normal self-antigens as well as abnormal or nonself antigens.

MHC I molecules present antigens to CD8+ T cells, which are involved in the cellular immune response.

These molecules are critical for the immune system's recognition of self and non-self antigens, distinguishing healthy cells from those infected by pathogens or affected by cancer.

Class 1 MHC molecules are encoded by the HLA-A, HLA-B, and HLA-C genes in humans.

When a cell becomes infected with an intracellular pathogen such as a virus, the MHC I molecules present pathogen-specific antigens on the surface of the infected cell, which signals to the immune system that the cell is compromised and should be targeted for destruction.

User Robert Brooks
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