Question

The _________ pathway involves stimulation of a TNF receptor on the cell leading to the formation of caspases resulting in apoptosis. The ______ pathway is stimulated by the release of cytochrome c from mitochondria leading to the formation of caspases resulting in apoptosis.

1) intrinsic, extrinsic
2) G protein mediated, protein-tyrosine kinase mediated
3) extrinsic, intrinsic
4) execution, initiation
5) protein-tyrosine kinase mediated, G protein mediated

Answer 1

The correct pathways involved in triggering apoptosis are the extrinsic pathway, via TNF receptor stimulation, and the intrinsic pathway, via cytochrome c release from mitochondria.

Step-by-step explanation:

The extrinsic pathway involves stimulation of a TNF receptor on the cell leading to the formation of caspases resulting in apoptosis. The intrinsic pathway is stimulated by the release of cytochrome c from mitochondria leading to the formation of caspases resulting in apoptosis. Therefore, the correct answer to the question is '3) extrinsic, intrinsic'.