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In the replication bubble in linear eukaryotic replication, what happens to the strands (leading/lagging)?

User DDelforge
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Final answer:

During eukaryotic replication, the leading strand is synthesized continuously in the direction of the replication fork, while the lagging strand is synthesized in short stretches using separate primers.

Step-by-step explanation:

Unlike prokaryotic chromosomes, eukaryotic chromosomes are linear. As you've learned, the enzyme DNA pol can add nucleotides only in the 5' to 3' direction. In the leading strand, synthesis continues until the end of the chromosome is reached. On the lagging strand, DNA is synthesized in short stretches, each of which is initiated by a separate primer. When the replication fork reaches the end of the linear chromosome, there is no place for a primer to be made for the DNA fragment to be copied at the end of the chromosome. These ends thus remain unpaired, and over time these ends may get progressively shorter as cells continue to divide.

User Jodast
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