Question

Which of the following projects would require mass array sequencing?

A) Genome-wide association studies for identifying genetic variants associated with diseases
B) Targeted mutation analysis in a specific gene for a hereditary disorder
C) Transcriptome analysis to study gene expression patterns in a large population
D) Population-wide microbial diversity assessment for environmental monitoring

Answer 1

A) Genome-wide association studies for identifying genetic variants associated with diseases.

Step-by-step explanation:

Mass array sequencing, also known as high-throughput sequencing, is particularly suited for large-scale projects involving the analysis of entire genomes. Genome-wide association studies (GWAS), which aim to identify genetic variants associated with diseases or traits, require the examination of a vast number of genomic regions across a large population. Mass array sequencing allows for the simultaneous sequencing of millions of DNA fragments, making it an efficient method for GWAS.

Options B, C, and D involve more focused analyses targeting specific genes, gene expression patterns, or microbial diversity, and might not necessitate the high-throughput capabilities of mass array sequencing. For targeted mutation analysis, Sanger sequencing or other targeted sequencing approaches may be more appropriate.

Option A is the answer.