Final answer:
Metaphase FISH is more suitable than karyotyping for detecting microdeletions in chromosome 15 associated with Angelman syndrome because it uses fluorescent probes to identify small deletions.
Step-by-step explanation:
For the accurate detection of microdeletion in chromosome 15 associated with Angelman syndrome, metaphase FISH (Fluorescence In Situ Hybridization) is considered to be a more suitable method than traditional karyotyping. While karyotyping can reveal genetic abnormalities such as extra chromosomes or large deletions, it is not as effective for detecting smaller microdeletions. Metaphase FISH, on the other hand, uses fluorescent probes that bind to specific regions of the chromosome, making it better suited for identifying small deletions characteristic of conditions like Angelman syndrome.