Final answer:
TH2 cells are the cell type responsible for regulating responses against predominantly extracellular pathogens. Hence the correct answer is option 2
Step-by-step explanation:
The cell type responsible for regulating responses against predominantly extracellular pathogens is TH2 cells. TH2 cells are a type of helper T cell that secrete cytokines to stimulate naïve B cells to destroy foreign invaders through antibody secretion.
Hence the correct answer is option 2