Final answer:
Intermediate filaments, which include proteins like keratin, play a structural role in cells, including being anchored at cell-cell junctions such as desmosomes, making the statement true.
Step-by-step explanation:
Intermediate filaments are important components of the cytoskeleton in eukaryotic cells. These structures are made of intertwined strands of fibrous proteins, most commonly a protein called keratin. The primary role of intermediate filaments is structural; they are crucial in bearing tension to maintain the cell's shape and anchoring organelles such as the nucleus in place.
Furthermore, intermediate filaments are indeed anchored to the plasma membrane at cell-cell junctions known as desmosomes. Desmosomes function to connect cells together in animal tissues, contributing to the overall structural integrity of the tissue. Therefore, the statement that intermediate filaments can be anchored to the plasma membrane at the cell-cell junction is true.