Final answer:
The primary difference between active transport and facilitated diffusion lies in the need for transporter proteins in active transport, while facilitated diffusion does not require transporter proteins.
Step-by-step explanation:
The primary difference between active transport and facilitated diffusion lies in the need for transporter proteins in active transport, while facilitated diffusion does not require transporter proteins. In active transport, transporter proteins move substances against their concentration gradient, requiring energy in the form of ATP. Facilitated diffusion, on the other hand, moves substances down their concentration gradient through specific protein channels in the membrane, without requiring energy. Therefore, option 2) 'Transporter proteins are required' is the correct answer.