Question

Which of the following would occur as a result of the inhibition of Na⁺,K⁺-ATPase?

1) Decreased intracellular Na⁺ concentration
2) Increased intracellular K⁺ concentration
3) Increased intracellular Ca₂⁺ concentration
4) Increased Na⁺-glucose cotransport
5) Increased Na⁺-Ca₂⁺ exchange

Answer 1

The inhibition of Na⁺,K⁺-ATPase would result in decreased intracellular Na⁺ concentration and increased intracellular K⁺ concentration.

Step-by-step explanation:

The inhibition of Na⁺,K⁺-ATPase would result in:

1. Decreased intracellular Na⁺ concentration
2. Increased intracellular K⁺ concentration
3. Increased intracellular Ca²⁺ concentration
4. Increased Na⁺-glucose cotransport
5. Increased Na⁺-Ca²⁺ exchange

When Na⁺,K⁺-ATPase is inhibited, the pump is unable to move Na⁺ out of the cell and K⁺ into the cell. This leads to an accumulation of Na⁺ inside the cell and a decrease in the intracellular Na⁺ concentration. At the same time, without the pump activity, K⁺ is unable to move into the cell, resulting in an increase in intracellular K⁺ concentration.