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You must subtract ____ ATP from the total ATP after cutting a carbon chain because it is used to turn the FFA into Acyl-CoA during activation and translocation?

User Forge
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Final answer:

You must subtract 2 ATP from the total ATP after cutting a carbon chain because it is used for the activation and translocation of Free Fatty Acids (FFA) into Acyl-CoA, during which one ATP is converted to AMP and pyrophosphate, amounting to a net usage of 2 ATP.

Step-by-step explanation:

During the metabolic process of fatty acid oxidation, particularly during the activation and translocation of Free Fatty Acids (FFA) to Acyl-CoA, there is a net utilization of energy. In this pathway, the conversion of one molecule of ATP to AMP and pyrophosphate is equivalent to the expenditure of 2 ATP. Thus, to calculate the total yield of ATP after complete beta-oxidation of a fatty acid, one must subtract 2 ATP from the total to account for the activation step.

For example, the complete oxidation of one molecule of palmitic acid (which has 16 carbons) through beta-oxidation produces 8 molecules of acetyl-CoA, leading to the generation of ATP via the citric acid cycle and oxidative phosphorylation. However, since the activation step utilizes one ATP molecule, which is equivalent to using up 2 ATP molecules, this amount must be deducted from the total yield.

Therefore, it is essential to subtract 2 ATP from the total ATP yield to account for the cost of converting FFA into Acyl-CoA. This adjustment in the calculation ensures that the energy tally reflects both the inputs and outputs of fatty acid catabolism accurately.

User Mo Beigi
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