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All of the following human genetic disease exhibits cytoplasmic maternal inheritance except?

1) Hemophilia
2) Leber's hereditary optic neuropathy
3) Myoclonic epilepsy
4) Kearns-Sayre syndrome

1 Answer

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Final answer:

Hemophilia does not show cytoplasmic maternal inheritance; it follows an X-linked recessive inheritance pattern. Diseases such as Leber's hereditary optic neuropathy, Myoclonic epilepsy, and Kearns-Sayre syndrome do follow mitochondrial inheritance.

Step-by-step explanation:

The question is asking which one of the listed human genetic diseases does not follow a pattern of cytoplasmic maternal inheritance. The diseases listed are Hemophilia, Leber's hereditary optic neuropathy, Myoclonic epilepsy, and Kearns-Sayre syndrome.

Hemophilia is a genetic disorder characterized by the inability of blood to clot properly. This disease follows an X-linked recessive inheritance pattern. This means that females can be carriers of the disease but usually do not show symptoms because they have a second, normal copy of the gene. Sons of female carriers have a 50% chance of inheriting the disease. Hemophilia does not exhibit cytoplasmic maternal inheritance because it is passed down via the X chromosome, not through the cytoplasm of cells as mitochondrial diseases are.

On the other hand, diseases like Leber's hereditary optic neuropathy, Myoclonic epilepsy, and Kearns-Sayre syndrome are examples of conditions that follow a mitochondrial inheritance pattern, meaning they are passed down from mothers to their children through the mitochondria in the cytoplasm of the egg cell.

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