Question

Consider a chromosome that has broken into two places to produce three chromosomal fragments. The middle fragment is lost and degraded. The rejoining of the two outer fragments will create a chromosome with a(n) _____ deletion?

Answer 1

Rejoining the two outer fragments after the middle fragment is lost creates a chromosome with a deletion mutation, where genetic information is lost, potentially leading to genetic diseases.

Step-by-step explanation:

If a chromosome breaks into two places and the middle fragment is lost and degraded, the rejoining of the two outer fragments will create a chromosome with a deletion. This type of mutation involves the loss of one or more nucleotides from a segment of DNA. Due to this change, the genetic information contained in that segment is lost, potentially leading to severe genetic diseases and disorders if the deleted genes play vital roles. Examples include cystic fibrosis, which can be caused by the deletion of three nucleotides resulting in the loss of the amino acid phenylalanine, and cat cry syndrome caused by a partial chromosome deletion.