Final answer:
Hemolytic anemia can be caused by trauma or splenic sequestration crisis, abnormal hemoglobin or enzyme deficiency, macroangiopathic or microangiopathic factors, and chronic diseases or medications and chemicals.
Step-by-step explanation:
Hemolytic anemia can be caused by several extrinsic factors. These include:
- Trauma or splenic sequestration crisis: Injuries or damage to the spleen can lead to the destruction of red blood cells.
- Abnormal hemoglobin or enzyme deficiency: Certain genetic conditions can result in abnormal hemoglobin or enzyme deficiencies, which can cause hemolytic anemia.
- Macroangiopathic or microangiopathic factors: Conditions that affect blood vessels, such as macroangiopathy and microangiopathy, can lead to the destruction of red blood cells.
- Chronic diseases or medications and chemicals: Some chronic diseases and certain medications or chemicals can trigger the destruction of red blood cells, leading to hemolytic anemia.