Final answer:
The E antigen is the second most immunogenic Rh antigen after the D antigen.
Step-by-step explanation:
After the D antigen, the most immunogenic of the Rh antigens is the E antigen. In the context of transfusion medicine and potential for immune reaction, the D antigen of the Rhesus (Rh) blood group system is the most likely to provoke an immune response in individuals who lack this antigen. However, for individuals who are D-negative, exposure to the E antigen can also lead to a significant immune response, making it the second most immunogenic Rh antigen.
This means that the D antigen is the most likely to provoke an immune response in individuals who do not have the antigen present on their red blood cells.