Final answer:
In 622, Muhammad and his followers fled to Yathrib (Medina) due to increasing aggression from the rulers of Mecca. This event is known as the hijra.
Step-by-step explanation:
In 622, Muhammad and his followers fled to Yathrib, which is later renamed Medina, due to increasing aggression and persecution by the rulers of Mecca. This event is known as the hijra or emigration. The people of Medina welcomed Muhammad and saw him as an impartial mediator in their frequent disputes.