Final answer:
The Plymouth colonists faced challenges such as lack of food and resources, harsh weather conditions, and conflict with Native Americans.
Step-by-step explanation:
The challenges faced by the Plymouth colonists included lack of food and resources, harsh weather conditions, and conflict with Native Americans. The Plymouth colonists, also known as the Pilgrims, faced a difficult first winter where many of them died due to starvation, disease, and cold. They were able to survive with the help of Native Americans, like Samoset and Squanto, who taught them how to grow corn and fish. However, conflicts with Native Americans over land eventually arose as the colonizers expanded.