Final answer:
Patrick Henry's statement 'separate and fight!' urged colonists to unite and resist British tyranny during the American Revolution.
Step-by-step explanation:
The statement 'separate and fight!' made by Patrick Henry had significant context and significance during the American Revolution. It was not an advocate for peaceful negotiation with the British (A) or for loyalty to the British Crown (B). Instead, Henry urged the colonists to unite and resist British tyranny (C). This statement was a call to action and reflected Henry's support for the American colonies' fight for independence.