Final answer:
Hamilton's letter to Harrison Gray Otis criticizes the rise of political parties in the early Republic.
Step-by-step explanation:
The letter from Hamilton to Harrison Gray Otis indicates the emergence of powerful partisan politics in the early Republic by showing Hamilton's criticism of the rise of political parties. In the letter, Hamilton expressed his concerns about factions and how they would obstruct the orderly operations of government. This criticism aligns with the development of the Federalist and Republican parties, which formed in opposition to each other over ideological differences.