Final answer:
African Americans were the cultural group that settled in South Carolina as enslaved people and had a significant impact on the colony's culture.
Step-by-step explanation:
The cultural group that settled in South Carolina were African Americans who were brought to the colony as enslaved people. They made up a significant portion of the population, with Africans outnumbering Europeans 2:1 by the 18th century. They were primarily brought to work in the rice fields and had a strong influence on the culture of South Carolina, eventually giving rise to the distinctive Gullah-Geechee culture.