Final answer:
George and Lennie are expected to face social conflicts at the ranch due to personality differences, Lennie's mental disability, and the tensions of the ranch environment during the Great Depression.
Step-by-step explanation:
The problems that George and Lennie are likely to face at the ranch in Steinbeck's 'Of Mice and Men' are best captured by option B: They will face social conflicts. Given their status as itinerant workers during the Great Depression and the personality differences between the two, combined with Lennie's mental disability and the generally tense environment of the ranch, they are likely to encounter difficulties with the other ranch hands, and maybe even the ranch's authority figures. These social dynamics and the prejudices of the time significantly contribute to the challenges that George and Lennie must navigate, leading to conflicts that drive the narrative forward.